Mitochondria Are More Than Powerhouses — They're the Motherboard of the Cell
Every cell biology class you ever took told you that mitochondria are the powerhouses of the cell. Martin Picard at Columbia argues that framing undersells them by about an order of magnitude. His research shows mitochondria function more like a central nervous system for cellular health: they sense stress, send signals to the nucleus, influence gene expression, and coordinate the body's response to everything from exercise to emotional trauma. The practical implication is that how you treat your body at the level of sleep, stress, and physical activity isn't just affecting your energy levels. It's shaping the intelligence of your cells.
Is the Secret to Men's Longevity a Great Butt?
The Wall Street Journal ran with a headline that sounds like a joke but the underlying research is serious. Glute strength turns out to be one of the strongest predictors of longevity in men, better than most biomarkers most people track obsessively. The mechanism makes sense: the glutes are the largest muscle group in the body, and their strength is a proxy for overall lower body power, metabolic health, and the kind of functional capacity that determines whether you can stay active and independent well into old age. Worth rethinking your training priorities if your current routine doesn't include anything that seriously loads the posterior chain.
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Long-Term Money
Morgan Housel opens with a fact that resets everything: Adam Smith wrote that it was common in 18th-century Scotland to meet a mother who had borne twenty children and had not two alive. Queen Anne of England had 18 children. Not one made it. Today we complain about grocery stores having too many options. The piece is a meditation on how profoundly life has improved in ways so total and complete that we've lost the ability to see them as progress. The compounding of human knowledge across generations is the most underrated investment thesis of all time, and this piece makes that case better than almost anything I've read.
A Navy SEAL Breathing Technique to Stay Calm and Focused
Former Navy SEAL Mark Divine's box breathing method has been around for years but I keep coming back to it. The technique is almost embarrassingly simple: inhale for four counts, hold for four, exhale for four, hold empty for four. What I find interesting is the physiology behind it. At 16 to 20 shallow breaths per minute, most people are running their nervous systems slightly hot all day. Slow that to five or six full breaths and you're running a completely different operating system. Divine practiced this standing in line, sitting in traffic, before workouts. The point isn't that breathing is magic. The point is that you have a direct line to your autonomic nervous system and almost nobody uses it.
The 12-month window
On a recent episode of No Priors, investor Elad Gil made an observation that's worth sitting with: for most companies there is roughly a 12-month period where the business is at peak value, and then it crashes out. Lotus, AOL, Mark Cuban's Broadcast.com all caught that window. A lot of great companies didn't. This matters especially right now because a significant portion of today's AI startup landscape exists because the foundation models haven't expanded into their category yet. As founders openly acknowledge, that won't last forever. The question for everyone building in this space is: do you know which phase you're in?
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How Not To Die - Chris DeMuth Jr
Vittorio is a biotech accelerationist and thinker exploring reality, how to transcend biology, and truth. He shares the science of how not to die, or at least how to live well, and his thoughts on human potential.
Doubling Down on your Winners
If a company is performing well (and communicating well), continue to invest in subsequent rounds. That follow-on capital can be just as important to overall fund returns as the initial investment.
18 months of Reflection - Sanjeev Agrawal
A personal essay detailing the author's deep introspection on life, career, and values after a major transition. It re-evaluates the pursuit of traditional achievement, noting that true joy was more often found in moments of physical mastery than in financial success.
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Gut Microbiome, Microbes & Mental Health: The Science of Stress
Emerging research shows that the microbes living in your gut may influence your stress levels, mood, and overall mental well-being. This article explores the gut-brain connection and the new wave of therapies aiming to improve mental health by targeting gut bacteria.
The 40-70 Rule: How to Make Decisions
A breakdown of General Colin Powell’s 40-70 decision-making framework: act when you have 40–70% of the information. It helps leaders avoid analysis paralysis while mitigating the risks of impulsive decisions.
10 Biohacking Trends for 2026 You Should Be Watching for Now
From glucose monitoring to brain stimulation and longevity-focused supplements, this article outlines cutting-edge biohacking innovations poised to shape health optimization in the near future.
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Nanowerk: Programmable Shape-shifting Materials Explores groundbreaking developments in materials that can alter their shape in response to environmental stimuli, with potential applications across robotics, biomedicine, and aerospace.
Discover Magazine: Quantum Sensors Navigate by Earth's Magnetic Field Highlights new quantum sensors that could revolutionize navigation systems by using Earth's magnetic field, eliminating the need for GPS.
Google Research Blog: Teaching Machines the Language of Biology Discusses how large language models are being adapted to understand biological data at the single-cell level, enabling breakthroughs in healthcare and biology research.
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What I Am Reading:
The secret history of Elon Musk, Sam Altman, and OpenAI
After three years, Elon Musk was ready to give up on the artificial intelligence research firm he helped found, OpenAI.
The nonprofit had launched in 2015 to great fanfare with backing from billionaire tech luminaries like Musk and Reid Hoffman, who had as a group pledged $1 billion. It had lured some of the top minds in the field to leave big tech companies and academia.
But in early 2018, Musk told Sam Altman, another OpenAI founder, that he believed the venture had fallen fatally behind Google, people familiar with the matter said.
And Musk proposed a possible solution: He would take control of OpenAI and run it himself.
Altman and OpenAI’s other founders rejected Musk’s proposal. Musk, in turn, walked away from the company — and reneged on a massive planned donation. The fallout from that conflict, culminating in the announcement of Musk’s departure on Feb 20, 2018, would shape the industry that’s changing the world, and the company at the heart of it.
What I Am Reading:
The Art of the Good Life: 52 Surprising Shortcuts to Happiness, Wealth, and Success
The Art of the Good Life is a toolkit designed for practical living. Here you'll find fifty-two happiness hacks -- from guilt-free shunning of technology to gleefully paying your parking tickets -- that are certain to optimize your happiness. These tips may not guarantee you a good life, but they'll give you a better chance (and that's all any of us can ask for).
Crazy Train
Semper Augustus Client Letter 2022
PROFITLESS PROSPERITY; INVESTING IN FLATION; AND – BERKSHIRE: GETTING BETTER ALL THE TIME
The Munger Operating System: How to Live a Life That Really Works
It’s such a simple idea. It’s the golden rule so to speak: You want to deliver to the world what you would buy if you were on the other end. There is no ethos, in my opinion, that is better for any lawyer or any other person to have. By and large the people who have this ethos win in life and they don’t win just money, not just honors. They win the respect, the deserved trust of the people they deal with, and there is huge pleasure in life to be obtained from getting deserved trust.
